There is an alphabet soup of blood derivatives out there, such as L-PRP, P-PRP, PPP, ACS, PRGF, and so on – each touted as being enriched in selected factors. However, research shows that the cells do not need an overdose of any factors, they need just the right ones in the right concentration. This physiological composition can create optimal results. Hyperacute serum is just that: the activated serum from the earliest phase of the healing cascade which has the highest proliferation supporting capacity without altering the lineage-determination of the cells. Hyperacute serum can be used in an autologous manner, i.e. harvested from the patient who is then receiving hypACTTM in the same medical procedure. For example, 18 ml blood is drawn in a routine way, then centrifuged, and processed to obtain hypACTTM which is transferred to a syringe. It is then reapplied in any way the physician sees fit, i.e. as an intraarticular injection in the knee. OrthoSera has developed a device which makes it easy and safe to isolate, process, and reapply hypACTTM in a closed system at the bedside. The device is CE marked and available for clinical use in Europe.